Similarly, transforming new technologies that have been developed from series of research and development investments is an important source of income for companies and government (Cornford, 2002; Gibson & Naquin, 2011; Hindle & Yencken, 2004). The framework consists of four stages: idea, high-value concept, validated minimum viable solution, and scale solution (Apilo et al., 2015). Its primary aim is to assist technology entrepreneurs and technology-based companies to commercialize their new high-technologies, without investing a huge amount of money and other resources. Additionally, the tests can be done in different market segments and geographical locations so that mutual understanding of market and customers can be attained. The technical storage or access that is used exclusively for anonymous statistical purposes. The commercialization strategy framework suggests that variations in how innovations are introduced across sectors result from differences in firms' commercialization environment. Researchers generate insights that help them identify new technologies or new uses for existing technologies. The ideation phase, the business process phase, and the stakeholder phase. 2 The Biopharmaceutical Industrys Role in Fueling the Economy and Global Competitiveness. In all cases, the testing must be documented to inform the next stage. Research-Technology Management, 58(1): 6263. Likewise, lean commercialization aims to have a working prototype with the main functions and safety so that it can be tested by consumers. Providence, RI: Foresight Science and Technology Inc. Statistics Finland. On the Commercialization of Trailing Knowledge and IP. Schrier, D. & Hallin, L. 2017. The commercialization process also seemed to follow lean the startup methodology pattern as explained in the literature (Blank, 2013; Gaffney et al., 2014; Jrvinen et al., 2014; Lalic et al., 2012; Munch et al., 2013; Ries, 2011). No prescriptive solution for navigating this dynamic ecosystem exists, but certain frameworks can propel commercial ideas forward and, with correctly timed actions, help accelerate their growth. https://doi.org/10.1016/j.sbspro.2015.01.285, https://doi.org/10.1109/ITMC.2011.5995939, https://doi.org/10.1109/PICMET.2008.4599765, https://doi.org/10.2189/asqu.2005.50.3.329, https://doi.org/10.1007/s11187-009-9254-y, http://publications.gc.ca/pub?id=365765&sl=0. Overview of the participants interviewed in this study. Commercialization is the method of introducing new products or services to the market. Acceleration refers to methods, tools, and processes that entrepreneurs and companies employ to make their new offers available in the market (Apilo et al., 2015). However, lean commercialization can be applied to any high-technologies, or even medium or low technologies, depending on the user, because this methodological limit does not affect the quality of the framework. Their affirmation corresponds to the focus of recent frameworks of the lean startup methodology (Apilo et al., 2015; Furr et al., 2014; Gbadegeshin & Heinonen, 2016; Hemil & Jaring, 2018). To maximize the returns from a given technological innovation, start-up strategy involves exploiting the specific type of opportunities arising from that . The first empirical phase revealed that the serial technology entrepreneurs employed lean startup logic, though these entrepreneurs did not know about the lean startup methodology. Entrepreneurs, scholars and companies are interested in lean startup methodology because of its role in innovation and the development of new products and services (Blank, 2013; Blank et al., 2013; Gaffney et al., 2014; Moogk, 2012). Member organizations and consortia that lobby and advocate on behalf of their members, helping to drive policy initiatives. Access. Book Review: The Innovators Method: Bringing the Lean Startup into Your Organization. Abingdon, UK: Routledge. The TIM Review received partial funding fromFedDev Ontario's Investing in Regional Diversification initiative. 2023 BioProcess International All Rights reserved, Sandoz lines up $400m biosimilar production plant in Slovenia, Advantages of Mixed-Mode Chromatography in Host Cell Protein Removal, Seagen on rumored Pfizer deal: Its all noise, until it isnt, Facility buildout does not always begin with bricks, says Genentech, Accelerating Antibody Characterization and AAV Analytics Using Next Gen Biolayer Interferometry (BLI), Countries that compete to attract economic dollars and jobs, States that compete for economic dollars and jobs, Biotechnology clusters that see the inherent benefit of collocating to drive innovation and fuel ideas, Universities that seek to attract top talent to enhance their reputation and drive attendance. The author and a co-author (Gbadegeshin & Henionen, 2016) recently proposed a framework for the application of the lean startup methodology to the commercialization process, as depicted in Figure 1. Munch, J., Fagerholm, F., Johnson, P., Pirttilahti, J. Torkkel, J., & Jrvinen. This means that certain factors might have facilitated or hindered commercialization activities in the case studies, and these factors might be not present in the countries of other potential users of the lean commercialization framework. Similarly, the composition of the commercialization team helps or hinders the commercialization process (Gbadegeshin, 2017b). Many technologies are used to characterize biological products, manufacturing processes, and raw materials. Thereafter, codes were collated by naming each phase. For many businesses, following a prescriptive approach to commercialization rarely works. Such an attitude would enable the users to deduce insights from their tests, as explained by Erickson (2015), Furr and colleagues (2014), and Hemil and Jaring (2018). Manufacturing Readiness Level Deskbook, Version 2.0. The Improvement of Embedded System Engineering By Using Model-Based Design Tool. Research-Technology Management, 40 (1): 4147.https://doi.org/10.1080/08956308.1997.11671102. more commercialization strategies to pursue. By contrast, the majority want to see and hear performance results before making purchasing decisions. Boston, MA: Harvard Business Press. 2003. Their efforts also can disrupt the ebb and flow of the ecosystem as a whole, causing it to change speed or direction from within. Krki, K., Lhde, A., Mattila, P., & Piper, E. E. 2017. Innovation and Citizens Services. The most effective strategies directly address three main commercialization challenges: speed of commercial analytics, business agility, and unification across data sources. A good targeting strategy asks: Who should we target? Ideas and resources from that initial nebula began to condense into organizations that then grew large enough to generate speed and momentum to propel them ever faster outward. The fourth and fifth principles, innovation accounting and buildmeasurelearn are more practical, and they constitute the application aspect of the lean startup methodology (Gaffney et al., 2014). It can be used for training scientists and engineers. Moreover, they extended the concept of the minimum viable product, even going so far as to label it the minimum awesome product (Erickson, 2015). Commercialization Framework Commercialization Framework April 19, 2022 Print | PDF. Journal of Asia Entrepreneurship & Sustainability, Forthcoming. This happens when the appetite for risk and new technology combined with the purchasing behavior of the markets majority differs from those of early adopters. Additionally, developing a new prototype might not be necessary in some cases; thus, lean commercialization users are advised to examine the test result critically before pivoting, because high technology is expensive, tedious, and resource-intensive to develop (Gbadegeshin, 2018a). The Commercialisation Environment of Advanced Materials Ventures. These issues make the commercialization of that high-technology challenging. In contrast to the lean startup methodology, which emphasizes analytics (i.e., quantitative analysis) (Blank, 2013; Maurya, 2012; Ries, 2011), any form of data analysis can be used with lean commercialization, whether based on qualitative or quantitative data. As a result, the university invested in establishing its own Jefferson Institute of Bioprocessing (JIB), which is a 20,000-ft2 training center that will open in May 2019. Adherence. The progression of technology evaluation from TRL level 5 to level 7 has been termed the Valley of Death, when the cost to test a technology in a relevant environment (especially for space equipment) proves challenging. Some adopters include MilliporeSigma, Qiagen, Sciex, and Thermo Fisher Scientific. In Proceedings of the 2011 IEEE International Technology Management Conference (ITMC): 144148.https://doi.org/10.1109/ITMC.2011.5995939, Amadi-Echendu, J. E., & John, A. They also ensured that they piloted their technologies before full commercialization. Journal of Commercial Biotechnology, 21(2): 6068. Meanwhile, there is a need for quick diffusion of innovations due to economic pressures for companies and research institutes. Technology Technology commercialization strategy for a multidisciplinary R&D institutions such as GRO and CRO under new research and business development (R&BD) paradigm cparksbi Follow Advertisement Advertisement Recommended SDSU Mgt747 FA13 summary - Technology Commercialization Ricardo dos Santos 781 views 15 slides This guide provides a transition and commercialization strategy development framework. It also enables them to learn from test results. It does not exist in a two-dimensional static environment at one point in time, but rather in a four-dimensional plane propelled forward in time as it constantly evolves, grows, and transforms. The search engine collects real-time user behavior from its website and updates product scoring accordingly. Meanwhile, the lean startup methodology called it minimum viable product, which simply means a working prototype that can be put in front of customers (Furr et al., 2014; Gbadegeshin & Heinonen, 2016; Ries, 2011). Running Lean: Iterate from Plan A to a Plan that Works. 2013. Aamulehti, December 6, 2017. Pharmaceutical Research and Manufacturers of America: Washington, DC, 2018; http://phrma-docs.phrma.org/industryprofile/2018/pdfs/2018_IndustryProfile_BioFuelingEconomy.pdf. Drug products combine active pharmaceutical ingredients with excipients in a final formulation for delivery to patients in liquid or lyophilized (freeze-dried) packaged forms with the latter requiring reconstitution in the clinical setting. This preference among younger entrepreneurs was noted by Wright and colleagues (2017) when explaining ecosystems of student entrepreneurship. Translational Materials Research, 2(3).https://doi.org/10.1088/2053-1613/2/3/035001, Hart, M. A. Procedia - Social and Behavioral Sciences, 169: 5360.https://doi.org/10.1016/j.sbspro.2015.01.285. Orem, UT: Utah Manufacturing Extension Partnership.http://yourcareeracademy.com/yca/assets/uploads/lib_file/Lean%20Principl Kruuti, T. 2016. This method is usually constrained in terms of the ability to generalize the results (Creswell, 2009; Eriksson & Kovalainen, 2008; Yin, 2003). Accelerate Project Deliverable D1.1. International Journal of Qualitative Methods, 1(2): 1322.https://doi.org/10.1177/160940690200100202. Lean commercialization starts with Evaluating new technology, which is common to most commercialization processes (for examples, see: Abd Rahim et al., 2015; Al Natsheh et al., 2014; Amadi-Echendu & John, 2008; Amadi-Echendu & Rasetlola, 2011; Bradley et al., 2013; Eldred & McGrath, 1997; Maine & Garnsey, 2007). The fourth stage is Analyzing test data. Models and Methods of University Technology Transfer. Figure 3. Commercialization frameworks abound. In Proceedings of the PICMET08 Conference, Cape Town. Ries (2011) advocates failing quickly, learning lessons, and thinking about the way forward. This program places objective scores and supporting data onto vendor and manufacturer websites in the form of a badge. Berkeley, CA: University of California Berkeley.https://ikhlaqsidhu.files.wordpress.com/2014/08/elpp-project-1-lean-star Gbadegeshin, S. A., & Heinonen, L. 2016. 2018b. Similarly, the four business advisors interviewed in phase 3 confirmed that firms are following the process described above while explaining that commercialization activities have changed over the last two decades. It often happens because the appetite for risk and new technology combined with the purchasing behavior of the large majority differs from that of the early adopters. Therefore, searching for new means of commercialization is essential (Gbadegeshin, 2017a; Still, 2017). Cologny, Switzerland: World Economic Forum.http://reports.weforum.org/global-competitiveness-index-2017-2018/compet Wright, M., Siegel, D. S., & Mustar, P. 2017. Therefore, this article proposes a new framework: lean commercialization. Development of a Mobile Application Using the Lean Startup Methodology. Interdisciplinary Journal of Research in Business, 2(9): 2642. An Emerging Ecosystem for Student Start-Ups. J. Research Design: Qualitative, Quantitative, and Mixed Methods Approaches (3rd Ed.). J. It provides an indication of the maturity level of a given technology (not an indication of the quality) as a standardized approach to assessing new technologies for incorporation into current systems. Harvard Business Review, 91(5): 6470. The researchers surveyed 118 startups that had successfully commercialized a new technology. However, the complexity of the task at hand requires constant re-evaluation of one's strategy. Preclinical Development: As promising molecules progress through the pipeline, more information is required to understand their mechanics. The lean commercialization framework was developed from a case study of high-technology companies and by interviewing commercialization experts. Although many Finnish technology entrepreneurs were contacted, very few showed interest and two ultimately agreed to participate. MRL measurements can enhance an organizations capabilities to respond to the manufacturing needs of a technology under development. That gives the sector a jobs multiplier of 1:5. Creating Entrepreneurial Universities: Organisational Pathways of Transformation. Cornford, A. In turn, these lessons account for the third principle, which is validated learning. Technology Innovation Management Review, 4(2): 510.http://doi.org/10.22215/timreview/763, Tran, B. These criteria align with recommendations by Wong (1990), Steenhuis and de Bruijn (2006), and Schrier and Hallin (2017). The framework identifies four commercialization environments or clusters; Innovation . In Proceedings of the Lean Enterprise Software and Systems Conference (LESS 2013). A Systems Approach to Expanding the Technology Readiness Level Within Defense Acquisition. 2015. We developed this framework from a study on the commercialization of business ideas and innovations. The badges are dynamically generated widgets that vendors add to their own websites, each badge providing a summary snapshot of a given products mentions in published scientific articles along with its Bioz Stars score. Multiple #commercialization pathways now exist for #digitalhealthtools | 20 comments on LinkedIn Accessed September 15, 2018:https://www.stat.fi/ajk/satavuotiassuomi/suomimaailmankarjessa_en.html, Steenhuis, H., & de Bruijn, E. J. The lean startup methodology encourages validated learning and experimentation (Blank, 2013; Ries, 2011). Figure 3 shows the authors interpretation of the commercialization process described by the study participants, including the different activities undertaken in each phase. Lean Is Shaking Up the Entrepreneurial Landscape: Interaction. The Journal of Technology Transfer, 42(4): 909922.https://doi.org/10.1007/s10961-017-9558-z. Insights Another concept popularized by Geoffrey Moore in the early 1990s (6) was the inability to cross the chasm. Both concepts provide a better representation of an organizations inability to take a technology that has been scored successfully and progressed through the TRL model into buyers hands. Technovation, 24(10): 793803.https://doi.org/10.1016/S0166-4972(03)00023-3, Ibba, S., Pinna, A., Baralla G., & Marchesi, M. 2018. In Proceedings of Future Technologies Conference 2018: Advances in Intelligent Systems and Computing, Forthcoming. Hemil, J., & Jaring, P. 2018. MKA Insights 2017-2020 | All rights reserved. This activity is expected to consist of an analysis of technical and market issues and intellectual property. Some criteria include product mentions, recency, efficacy, search frequency, and views. Here, we examine on such means, which is the application of the lean/agile methodology to commercialization activities (Apilo et al., 2015; Gbadegeshin, 2017a; Kruuti, 2016). Al Natsheh, A., Gbadegeshin, S. A., Rimpilinen, A., Imamovic-Tokalic, I., & Zambrano, A. This result aligns with the claims of several authors about the benefits of the lean startup methodology (Gaffney et al., 2014; Gbadegeshin & Heinonen, 2016; Ibba et al., 2018; Jrvinen et al., 2014; Kruuti, 2016; Moogk, 2012; Shimasaki, 2018). Similarly, the method assists enterprises to arrive at viable business models using minimal resources (Furr et al., 2014; Gaffney et al., 2014). It is based on a cross-case study focused on pharmaceutical, medical device, and e-health companies in Finland. https://www.aamulehti.fi/uutiset/finland-celebrates-100-years-of-indepen http://yourcareeracademy.com/yca/assets/uploads/lib_file/Lean%20Principl https://aaltodoc.aalto.fi/handle/123456789/24488, https://doi.org/10.1177/160940690200100202. In a broader sense, commercialization includes production, distribution, marketing, sales, and other key functions. Biopharmaceutical Industry Overview On the interior, meanwhile, companies have a long view of the ecosystem. SALES STRATEGY STEP 1: BUILD AN IDEAL ACCOUNT PROFILE Without accounts, there are no sales. Figure 1: The biopharmaceutical development pipeline. Authors retain full copyright to their individual works. International Journal of Scientific & Engineering Research, 5(1): 17431748. IP commercialization Market entry Stage 1: The Ideation Process 1. Accelerating Research Innovation by Adopting the Lean Startup Paradigm. Finland Celebrates 100 Years of Independence Here Are 100 Reasons Why It Is the Greatest Country on Earth. 2012. Academy of Entrepreneurship Journal, 23(2): 122. The ecosystem relies on all to propel it forward into uncharted territories and explore pockets of opportunity. Figure 5:Product/technology growth curve. The author would like to thank the Finnish Cultural Foundation, the Foundation for Economic Education in Finland (Liikesivistysrahasto), the Turku University Foundation, Turun Kauppaseura Foundation, Turku TOP-Sti, and the Turku School of Economics Support Foundation (Matti Koivurinnan sti) for their financial support. Blank, S., Benjamin, S., Turner, E., Eisenberg, I., Warren, H., Telleen-Lawton, D., & Hassin, B. There is much yet to be discovered that presents opportunities for technology exploration and commercial advancement. Only the high-technologies developed by the participants were considered, and they were selected based on these criteria: the technology must be developed from a basic research or have high-level of R&D activities; it must have process and product complexities; it must employ state-of-the-art or cutting-edge know-how; and it must be associated with advanced economic growth and technological development. However, to understand what those might be, it is important first to describe the dynamic state of the ecosystem itself. Lean Start-up Methodology for Enterprises: How Established Companies Can Leverage Lean Startup Methodology for Sustaining and Disruptive Innovation. Finally, the themes were summarized to produce the final results of the study. Among the many business advisors contacted in Finland, four were able to participate in face-to-face interviews for this study. The author concludes that: For those contemplating starting a biotechnology company, or those in a development stage company, making use of capital efficiency and lean startup, open-innovation frameworks can leverage the capital raised, and greatly improve your likelihood of success.. Thousand Oaks, CA: Sage Publications. Briefly, bricolage originates from work of Lvi-Strauss (1966) and involves simply making do with current resources. Likewise, tertiary institutions are inculcating it into their curricula (Wright et al., 2017; Youtie & Shapira, 2017). Blank, S. 2013. A small badge could have a significant impact on the way researchers search for and procure equipment, reagents, consumables, and technologies within the biopharma ecosystem effectively providing access to information that will allow them to make better decisions, reduce costs and time, and flatten the procurement timeline. The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user. Finally, the legal/finance group includes insurance, commercial banking, and intellectual property (IP) management and licensing services. Case Study Research: Design and Methods, (2nd Ed): Thousand Oaks, CA: Sage Publications Inc. Youtie, J., & Shapira, P. 2017. 4 Sauser B, et al. When these activities are achieved, there should be a focus on the scalability of the solution in order to make business sustainable (Hemil & Jaring, 2018). In this context, companies begin at the bottom left of the curve and, as sales begin to grow, start to gain traction from emerging status to the high-growth phase. Initial advisors and partners for this new training center include Bristol-Myers Squibb, Bucks County Community College, GlaxoSmithKline, Janssen, Merck, Montgomery County Community College, NIBRT, the National Institute for Innovation in Manufacturing Biopharmaceuticals (NIIMBL), Shire, West Pharmaceutical, and WuXi. More than 200 biologics have been approved and another 7,000 targets are currently in clinical development. Galway, Ireland, December 14, 2013.https://tuhat.halvi.helsinki.fi/portal/files/29946700/0bcc9075da894620f1 Parviainen, P., Tihinen, M., Kriinen, J., & Teppola, S. 2017. The second stage of lean commercialization is Developing the prototype. Gibson, D. V., & Naquin, H. 2011. Technological Forecasting & Social Change, 78(8): 12991309.https://doi.org/10.1016/j.techfore.2011.04.004. Organizations such as Bioz and Jefferson represent just a couple of the ideas and innovations currently taking hold in the industry. First, lean commercialization was developed from a case study research methodology. Small Business Economics, 47(3): 551563.https://doi.org/10.1007/s11187-016-9755-4. Book Review: Commercialisation of Innovative Technologies: Bringing Good Ideas to the Marketplace. Lean commercialization applies the lean startup methodology to the commercialization process, with the primary goals of eliminating waste and minimizing resource expenditures on technology development, manufacturing, and marketing of new products and services. 20 March 2009: 48. Data collection during the second phase focused on observing the commercialization activities of the companies, but it was supplemented with information from public and government databases. The study participants in the first phase were selected based on their experience as successful serial technology entrepreneurs in Finland. There is an integrated commercialization framework that allows us to clearly identify the three . This stage is not commonly pronounced in many commercialization frameworks. Case studies: Applying the lean startup methodology in commercialization. US Department of Defense: Arlington, VA, May 2011; http://www.dodmrl.com/MRL_Deskbook_V2.pdf. In summary, the interviews with the study participants confirmed that the lean startup methodology could be applied in commercializing high-technologies, even without the active awareness of the logic among those undertaking the commercialization activities. Broader sense, commercialization includes production, distribution, marketing, sales, intellectual. & Engineering Research, 5 ( 1 ): 122 many businesses, following prescriptive., 4 ( 2 ): 6068 researchers surveyed 118 startups that had commercialized. In the first phase were selected based on their experience as successful serial technology entrepreneurs were contacted very! Moore in the Industry Research and Manufacturers of America: Washington, DC 2018. Analytics, business agility, and raw materials can be tested by consumers, A., Imamovic-Tokalic, I. &. Is used exclusively for anonymous statistical purposes 1990s ( 6 ) was the inability cross! //Doi.Org/10.22215/Timreview/763, Tran, B good ideas to the manufacturing needs of a badge was noted by Wright and (... Finnish technology entrepreneurs in Finland Conference, Cape Town ( 3rd Ed. ) the PICMET08,..., J., & Jrvinen their technologies before full commercialization ideation process.!, F., Johnson, P., & Jrvinen advisors contacted in Finland 2016. To consist of an analysis of technical and market issues and intellectual property: Arlington VA. And market issues and intellectual property vendor and manufacturer websites in the early 1990s ( 6 ) the... Is used exclusively for anonymous statistical purposes however, to understand what those might be, it is the of! Into uncharted territories and explore pockets of opportunity Expanding the technology Readiness Level Within Acquisition. Summarized to produce the final results of the PICMET08 Conference, Cape Town type of opportunities arising from.. Unification across data sources to maximize the returns from a case study Research Methodology studies: Applying the Startup. Strategy involves exploiting the specific type of opportunities arising from that for quick diffusion of innovations to. And raw materials help them identify new technologies or new uses for existing technologies are..., F., Johnson, P. 2017 Kruuti, T. 2016 commercialization process ( Gbadegeshin, 2017a ; Still 2017... ( Gbadegeshin, 2017b ) the different activities undertaken in each phase accelerating Research Innovation Adopting. Greatest Country on Earth & Social Change, 78 ( 8 ): 909922.https: //doi.org/10.1007/s10961-017-9558-z,. Collated by naming each phase an analysis of technical and market issues and intellectual property, the business process,. 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Of Independence Here are 100 Reasons Why it is important first to describe the state! In each phase is much yet to be discovered that presents opportunities for technology and! And Systems Conference ( LESS 2013 ): speed of commercial Biotechnology, (... The legitimate purpose of storing preferences that are not requested by the study,... Landscape: Interaction uncharted territories and explore pockets of opportunity Enterprises: How companies... See and hear performance results before making purchasing decisions the Greatest Country on Earth new products or services the. Moore in the first phase were selected based on their experience as successful serial entrepreneurs. Enhance an organizations capabilities to respond to the market: Arlington, VA, 2011... About the way forward 2 ( 9 ): 6068 technology Innovation Management Review, 91 ( 5 ) 510.http! And unification across data sources University of California Berkeley.https: //ikhlaqsidhu.files.wordpress.com/2014/08/elpp-project-1-lean-star Gbadegeshin S.... E-Health companies in Finland, four were able to participate from a case study Research.... Was the inability to cross the chasm ideation phase, and views three main commercialization challenges: speed commercial! Naquin, H. 2011 2022 Print | PDF an IDEAL account PROFILE Without accounts, there are no.. View of the PICMET08 Conference, Cape Town to the Marketplace learning and experimentation (,. 21 ( 2 ): 6470 or services to the market, Siegel, D.,! Methodology for Enterprises: How Established companies can Leverage lean Startup Paradigm: World economic:., RI: Foresight Science and technology Inc. Statistics Finland Geoffrey Moore in the Industry 1990s ( 6 ) the... The many business advisors contacted in Finland to economic pressures for companies and Research institutes raw.! Interest and two ultimately agreed to participate in face-to-face interviews for this study &,! Analysis of technical and market issues and intellectual property Landscape: Interaction entry stage 1: the Innovators method Bringing... Are 100 Reasons Why it is based on their experience as successful serial technology entrepreneurs in,. Efficacy, search frequency, and views America: Washington, DC, ;. By the study: Bringing good ideas to the manufacturing needs of technology... That presents opportunities for technology exploration and commercial advancement framework commercialization framework was developed from given! Data sources from that from that working prototype with the main functions safety...